Hizo no Kasamushi is one of the 63 creepy germs written in Harikikigaki, a book of medical knowledge written in 1568 by a unknown resident of Osaka. This tiny malevolent creature is believed to cause human illness during the 16th century in Japan.

Hizo no Kasamushi is a worm found in the spleen. It causes its host to gain or lose weight based on the amount of food he eats.

The herbs agi (giant fennel) and gajutsu (purple turmeric) are effective in controlling Hizo-no-kasamushi.

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